Mechanism of Platelet Activation and Hypercoagulability by Antithymocyte Globulins (ATG)
نویسندگان
چکیده
منابع مشابه
Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion.
Antithymocyte globulins (ATGs), the immunoglobulin G (IgG) fraction of sera from rabbits or horses immunized with human thymocytes or T-cell lines, are used in conditioning regimens for bone marrow transplantation, in the treatment of acute graft-versus-host disease, in the prevention or treatment of acute rejection in organ transplantation, and in severe bone marrow aplasia. In nonhuman primat...
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The induction of immunological tolerance to solid organ allograft is currently a subject of major investigation due to the morbidity and mortality related to immunosuppressive therapy. Immunosuppression induction by recipient treatment may allow to tailoring the timing and dosage of standard therapy not only reducing adverse reactions but also improving the graft outcome. Depletion of recipient...
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BACKGROUND To identify the mechanisms of the hypercoagulability associated with antiphospholipid antibodies, we investigated antibody-mediated platelet activation and interference of antibodies with phospholipid-dependent reactions. DESIGN AND METHODS We used two murine monoclonal antibodies, one against beta(2)-glycoprotein I (7F6G), the other against prothrombin (28F4). Platelet activation ...
متن کاملPharmacokinetics and pharmacodynamics of two antithymocyte globulins in treatment of pediatric aplastic anemia.
OBJECTIVE To compare the pharmacokinetics and pharmacodynamics of antithymocyte globulins (ATGs) produced by two companies in the treatment of children with aplastic anemia (AA). METHODS Six children with acquired AA were divided into two groups. The patients in each group were treated with either R-ATG or F-ATG for 5 consecutive days. Venous blood samples were collected at time points of 0 h...
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Familial hemophagocytic lymphohistiocytosis (FHL) is a potentially fatal disease characterized by diffuse infiltration by histiocytes and T lymphocytes. Treatment with myelotoxic drugs, such as etoposide, brings about remission in most patients, but problems of toxicity remain, and the development of disease resistance can cause secondary relapses. We have used an alternative approach, based on...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2015
ISSN: 1600-6135
DOI: 10.1111/ajt.13316